How does it work precisely?
Chronic persistent inflammatory pain is primarily transmitted through activation of afferent C- fiber pathways (and some A delta fibers), whereas the sense of touch and acute pain signals are transmitted through different subsets of nerves. Therefore, the C-fibers are a prime target for research into chronic pain control.
Medical professionals typically treat chronic pain with NSAIDs to reduce pain and inflammation locally or with opioids to modify the brain’s perception of pain levels centrally. Despite the drugs’ effects, key receptors continue to signal tissue damage. Over time, the central nervous system tends to exacerbate pain signals (called sensitization to pain). This physiological mechanism loop explains why most pain medications lose effectiveness over time and require dose adjustments or a change in therapy (class of drugs used).
RTX is a purified, active, non-opioid compound that is naturally selective and strongly binds to calcium channel gates found on C-fibers (and some A delta nerve fibers). With their calcium channel gates blocked open, substantial amounts of calcium ions enter the cell body, naturally triggering cellular programmed death (apoptosis).